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RMS5, a tetrandrine analogue, is a potent P-glycoprotein (P-gp) inhibitor. RMS5 has markedly antiproliferative and cytotoxic effects on cancer cells. RMS5 slightly diminishes the expression of the anti-apoptotic Bcl-2 family proteins Bcl-XL and Mcl-1. RMS3 causes PARP cleavage, a marker for cells undergoing apoptosis. RMS5 has strong anticancer property[1].

[1] RamonaSchütz, et al. Synthesis, biological evaluation and toxicity of novel tetrandrine analogues. Eur J Med Chem. 2020 Dec 1;207:112810. DOI:10.1016/j.ejmech.2020.112810