2496515-38-7

Galectin-3-IN-4 (compound 5) is a carboxamide analog. Galectin-3-IN-4 is a potent, selective, and orally bioavailable inhibitor of human and mouse galectin-3, with IC50 values of 21 and 167 nM for hGal-3 and mGal-3, respectively. Galectin-3-IN-4 has IC50 values of 1580 and 2750 nM for hGal-1 and hGal-9, respectively[1].

Galectin-3: 21 nM (IC₅₀, hGal-3); Galectin-3: 167 nM (IC₅₀, mGal-3); Galectin-1: 1580 nM (IC₅₀, hGal-1)

[1] Liu C, et al. Identification of benzothiazole derived monosaccharides as potent, selective, and orally bioavailable inhibitors of human and mouse galectin-3; a rare example of using a S···O binding interaction for drug design. Bioorg Med Chem. 2024 Mar 1;101:117638. DOI:10.1016/j.bmc.2024.117638