Physical properties
Ethylene vinyl acetate is available as white waxy solids in pellet or
powder form. Films are translucent.
Uses
Flexible tubing, color concentrates, gaskets and molded parts for autos, plastic lenses and pumps.
Production Methods
Various molecular weights of random ethylene vinyl acetate
copolymers can be obtained by high-pressure radical polymerization,
bulk continuous polymerization, or solution polymerization.
General Description
Poly(ethylene-co-vinyl acetate) (PEVA) is a flame-retardant material with good mechanical and physical properties. It is majorly used as an insulating material in wire and cable industry.
Pharmaceutical Applications
Ethylene vinyl acetate copolymers are used as membranes and
backings in laminated transdermal drug delivery systems. They can
also be incorporated as components in backings in transdermal
systems. Ethylene vinyl acetate copolymers have been shown to be
an effective matrix and membrane for the controlled delivery of
atenolol triprolidine, and furosemide. The system for the
controlled release of atenolol can be further developed using
ethylene vinyl acetate copolymers and plasticizers.
Safety
Ethylene vinyl acetate is mainly used in topical pharmaceutical
applications as a membrane or film backing. Generally it is regarded
as a relatively nontoxic and nonirritant excipient.
storage
Ethylene vinyl acetate copolymers are stable under normal
conditions and should be stored in a cool, dry place. Films of
ethylene vinyl acetate copolymers should be stored at 0–30°C and
less than 75% relative humidity.
Incompatibilities
Ethylene vinyl acetate is incompatible with strong oxidizing agents
and bases.
Regulatory Status
Included in the FDA Inactive Ingredients Database (intrauterine
suppository; ophthalmic preparations; periodontal film; transdermal
film). Included in nonparenteral medicines licensed in the UK.
