TNIK&MAP4K4-IN-1 (compound A-39) is a dual inhibitor of TNIK and MAP4K4/HGK with IC50s of 1.29 nM and <10 nM，respectively，in human hepaticstellate cell LX-2. TNIK&MAP4K4-IN-1 can be used for cancer and fibrosis inhibition[1].
References
[1] Aliper A, et al. TNIK and/or MAP4K4 kinase inhibitors and therapeutic uses thereof in treatment of cancer and fibrosis. World Intellectual Property Organization, WO2020170203 A1 2020-08-27.
