2454113-83-6

Name	3-Thiazolidineacetamide, N-2-benzothiazolyl-5-(2-furanylmethylene)-2,4-dioxo-
CAS	2454113-83-6
Molecular Formula	C17H11N3O4S2
Molecular Weight	385.42
MOL File	2454113-83-6.mol

Synonyms

GLUT4-IN-2 3-Thiazolidineacetamide, N-2-benzothiazolyl-5-(2-furanylmethylene)-2,4-dioxo-

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Chemical Properties

density	1.618±0.06 g/cm3(Predicted)
form	Solid
pka	8.61±0.70(Predicted)
color	Off-white to light yellow

Hazard Information

Uses

GLUT4-IN-2 is a potent and selective GLUT4 inhibitor with IC50s of 11.4 μM and 6.8 μM for GLUT1 and GLUT4, respectively. GLUT4-IN-2 induces cell apoptosis and cell cycle arrest at G0/G1phase. GLUT4-IN-2 shows potent antitumor activity[1].

in vivo

GLUT4-IN-2 (50 mg/kg; i.p. on day 1–5, 8–12, 15–18) shows antitumor activity in CEM xenograft model^[1].

Animal Model:	8–10 weeks, SCID mice (CEM xenograft tumor) ^[1]
Dosage:	50 mg/kg
Administration:	I.p.; administered on day 1-5, 8-12, 15-18
Result:	Showed potent antitumor activity in vivo.

IC 50

GLUT1: 11.4 μM (IC₅₀); GLUT4: 6.8 μM (IC₅₀)

References

[1] Tilekar K,et al. Structure guided design and synthesis of furyl thiazolidinedione derivatives as inhibitors of GLUT 1 and GLUT 4, and evaluation of their anti-leukemic potential. Eur J Med Chem. 2020 Sep 15;202:112603. DOI:10.1016/j.ejmech.2020.112603

Supplier

Shanghai Beckham Medical Technology Co., Ltd

Telephone021-13816613772 13816613772

Websitehttps://www.chemicalbook.com/ShowSupplierProductsList16976/0.htm

Guangzhou Younan Technology Co., Ltd

Telephone020-82000279 18988968278

Websitehttp://www.ubiochem.cn/

Shanghai Yifei Biotechnology Co. , Ltd.

Telephone021-65675885 18964387627

Websitehttp://www.efebio.com

TargetMol Chemicals Inc.

Telephone 15002134094

Websitehttps://www.targetmol.cn/

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