2433837-65-9

EGFR-IN-69 (compound 17g) is a potent EGFR inhibitor, with IC50 values of 4.3, 6.6 and 25.6 nM against EGFRL858R/T790M/C797S, EGFRL858R/T790M, and EGFR19del/T790M/C797S, respectively. EGFR-IN-69 can be used for non-small-cell-lung-cancer (NSCLC) research[1].

EGFR L858R/T790M/C797S: 4.3 ± 0.9 nM (IC₅₀); EGFR^L858R/T790M: 6.6 ± 0.8 nM (IC₅₀); EGFR^{del19 T790M C797S}: 25.6 ± 7.5 nM (IC₅₀); EGFR^WT: 816.0 ± 82 nM (IC₅₀)

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[1] Chen H, et al. Conformational Constrained 4-(1-Sulfonyl-3-indol)yl-2-phenylaminopyrimidine Derivatives as New Fourth-Generation Epidermal Growth Factor Receptor Inhibitors Targeting T790M/C797S Mutations. J Med Chem. 2022 May 12;65(9):6840-6858. DOI:10.1021/acs.jmedchem.2c00168