2411441-54-6

NOD2 antagonist 1 (compound 32) is a potent and selective NOD2 antagonist with an IC₅₀ of 5.23 μM. NOD2 antagonist 1 inhibits Muramyl dipeptide (MDP)-induced IL-8 secretion in THP-1 cells and inhibits MDP-induced IL-6, IL-10, TNF-α release in PBMCs^[1].

NOD2 antagonist 1 (compound 32) is a potent and selective NOD2 antagonist with an IC50 of 5.23 μM. NOD2 antagonist 1 inhibits Muramyl dipeptide (MDP)-induced IL-8 secretion in THP-1 cells and inhibits MDP-induced IL-6, IL-10, TNF-α release in PBMCs[1].

NOD2: 5.23 μM (IC₅₀)

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[1] Guzelj S, et al. Structural features and functional activities of benzimidazoles as NOD2 antagonists. Eur J Med Chem. 2020;190:112089. DOI:10.1016/j.ejmech.2020.112089