ANT3310 sodium (intravenous injection, 25-100 mg/kg, at 1, 3, 5, and 7 h postinfection) reduces bacterial burdens in murine thigh infection model[1].
ANT3310 sodium (intravenous injection, 1 mg/kg, Male Swiss albino mice) shows a T1/2 value of 0.64 h, AUC value of 412 ng?h/mL, and Cl value of 40 mL/min/kg (pharmacokinetic assay)[1].
| Animal Model: | Murine thigh infection model[1] |
| Dosage: | 25, 50, and 100 mg/kg |
| Administration: | Intravenous injection, at 1, 3, 5, and 7 h postinfection |
| Result: | Reduced bacterial burdens (colony forming units, CFU) in a dose-dependent manner to levels below that of the initial starting inoculum at the highest dose, when treated with the combination of MEM. |
