NP3-562 is a potent, orally active, tricyclic NLRP3 Inhibitor, with an IC50 of 214 nM. NP3-562 (30 mg/kg, p.o.) inhibits IL-1β release in a mouse acute peritonitis model[1].
IC 50
NLRP3: 214 nM (IC50)
References
[1] Juraj Velcicky, et al. Discovery of Potent, Orally Bioavailable, Tricyclic NLRP3 Inhibitors. J Med Chem. 2024 Jan 4. DOI:10.1021/acs.jmedchem.3c02098
