2407610-46-0

Name	1,2,5-Thiadiazolidin-3-one, 5-(1-fluoro-3-hydroxy-7-methoxy-2-naphthalenyl)-, 1,1-dioxide
CAS	2407610-46-0
Molecular Formula	C13H11FN2O5S
Molecular Weight	326.3
MOL File	2407610-46-0.mol

Synonyms

Tegeprotafib 5-(1-fluoro-3-hydroxy-7-methoxy-2-naphthyl)-1,1-dioxo-1,2,5-thiadiazolidin-3-one 1,2,5-Thiadiazolidin-3-one, 5-(1-fluoro-3-hydroxy-7-methoxy-2-naphthalenyl)-, 1,1-dioxide

show less show more

Chemical Properties

density	1.600±0.06 g/cm3(Predicted)
form	Solid
pka	3.19±0.20(Predicted)
color	White to off-white

Hazard Information

Uses

Tegeprotafib (PTPN2/1-IN-1) (Compound 124) is an orally active PTPN1 and PTPN2 inhibitor with IC50s of 4.4 nM and 1-10 nM against PTPN2 and PTP1B, respectively[1].

in vivo

Tegeprotafib (Compound 124; 300 mg/kg; oral; BID for 21 days) shows antitumor activity in mice^[1].

Animal Model:	Female C57B1/6 mice, MC-38 tumor model^[1]
Dosage:	300 mg/kg/dose
Administration:	Oral, twice a day (BID) at 7am and 5pm for 21 days
Result:	Within 7-10 days of treatment, apparent tumor stasis and shrinkage was observed. 50% of mice achieved complete cures, and an overall TGI_MEX was 75%. The frequency of functional, granzyme B (GzB) producing cells within the cytotoxic CD8+ T population in the spleen was 2.9-fold increased over vehicle control treated animals. Increased IP10 levels in plasma.

References

[1] Elliot FARNEY, et al. Protein tyrosine phosphatase inhibitors and methods of use thereof. Patent WO2019246513A1.

Supplier

Dezhou LonWel Pharmaceutical Technology Co., Ltd.

Telephone 13761310616

Websitehttps://www.chemicalbook.com/ShowSupplierProductsList20080/0.htm

Nantong QuanYi Biotechnology Co., Ltd

Telephone0513-66337626 18051384581

Websitehttps://www.chemhifuture.com/

PharmaBlock Sciences (Nanjing), Inc.

Telephone4000255188 4000255188

Websitehttps://www.pharmablock.com/

TargetMol Chemicals Inc.

Telephone 15002134094

Websitehttps://www.targetmol.cn/

Suzhou ARTK Medchem Co., Ltd.

Telephone+86-512-68323658 +86-18168183658

Website

PROMPT×

PROMPT
The What'sApp is temporarily not supported in mainland China

Cancel

Determine

Send Inquriy