ChemicalBook CAS DataBase List 2390-54-7

2390-54-7

Name	Thioflavine T
CAS	2390-54-7
EINECS(EC#)	219-228-9
Molecular Formula	C17H19ClN2S
MDL Number	MFCD00011944
Molecular Weight	318.86
MOL File	2390-54-7.mol

Chemical Properties

Appearance	yellow to ochre-yellow powder
Melting point	211-212 °C (decomp)
density	1.301g/cm3 at 20℃
vapor pressure	0Pa at 25℃
storage temp.	Store below +30°C.
solubility	methanol: soluble1mg/mL
Colour Index	49005
form	Powder
color	Yellow to ochre-yellow
BRN	3922452
LogP	3.02 at 25℃ and pH7.98
Uses	Textile dyeing, fluorescent sign paints, in combination with green or blue pigments to produce brilliant greens, phosphotungstic pigments. less more
CAS DataBase Reference	2390-54-7(CAS DataBase Reference)
EPA Substance Registry System	2390-54-7(EPA Substance)

Safety Data

Safety Statements	S24/25:Avoid contact with skin and eyes . less more
RIDADR	2811
WGK Germany	3
TSCA	Yes
HazardClass	6.1(b)
PackingGroup	III
HS Code	32041300

Hazard Information

Chemical Properties

yellow to ochre-yellow powder

Definition

ChEBI: Thioflavine T is an organic chloride salt having 2-[4-(dimethylamino)phenyl]-3,6-dimethyl-1,3-benzothiazol-3-ium as the counterion. It is widely used to visualise and quantify the presence of amyloids, both in vitro and in vivo. It has a role as a fluorochrome, a histological dye and a geroprotector. It contains a thioflavin T cation.

Preparation

4-(6-Methyl-2,3-dihydrobenzo[d]thiazol-2-yl)benzenamine?with methanol and hydrochloric acid or sulfuric acid, at 160 ~ 170 ℃ methylation under pressure.

General Description

Thioflavin T is a benzothiazole dye that increases in fluorescence upon binding to amyloid. Thioflavin T has been used in histology and for protein characterization.

Biochem/physiol Actions

Cell permeable: yes

storage

Store at -20°C

Properties and Applications

colourful green light yellow. Soluble in cold water, soluble in hot water for yellow, easily soluble in ethanol and yellow, with green fluorescent. The strong sulfuric acid to colorless, a green fluorescent, diluted into light yellow.

Standard( Silk )	Light Fastness	Persperation Fastness		Ironing Fastness		Soaping
Standard( Silk )	Light Fastness	Fading	Stain	Fading	Stain	Fading	Stain
C	3	2-3		4		1

Purification Methods

Crystallise the chloride from *benzene/EtOH (1:1). [Beilstein 27 III/IV 5052.]

Material Safety Data Sheet(MSDS)

Spectrum Detail

Well-known Reagent Company Product Information

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