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PAN endonuclease-IN-1 (Compound 23) is a potent PAN endonuclease inhibitor, with Kd values of 277 μM, 384 μM and 328 μM for WT, I38T and E23K PAN endonucleases, respectively. The RNA-dependent RNA polymerase acidic N-terminal (PAN) endonuclease, a critical component of influenza viral replication machinery, is an antiviral target[1].

[1] Alysia J Kohlbrand, et al. Structural Studies of Inhibitors with Clinically Relevant Influenza Endonuclease Variants. Biochemistry. 2024 Jan 8. DOI:10.1021/acs.biochem.3c00536