2376590-40-6

PPARα agonist 2 (compound 4u) is a potent and selective PPARα agonist with an EC50 of 37 nM. PPARα agonist 2 exhibits >2,700-fold selectivity for PPARα over other PPAR isoforms. PPARα agonist 2 has the potential for retinal disorders research[1].

CAY10767 is an agonist of peroxisome proliferator-activated receptor α (PPARα; EC50 = 37 nM in a reporter assay).1 It is greater than 2,700-fold selective for PPARα over PPARγ or PPARδ.

PPARα: 37 nM (EC₅₀)

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1.Dou, X., Nath, D., Shin, H., et al.Evolution of a 4?benzyloxy-benzylamino chemotype to provide efficacious, potent, and isoform selective PPARα agonists as leads for retinal disordersJ. Med. Chem.63(6)2854-2876(2020)