Uses
STING agonist-21 (compound 1) is a STING agonist, with an EC50 of 592.8 nM. STING agonist-21 can be used for cancer research[1].
Biological Activity
SR-301 is an orally bioavailable analog of the selective STING agonist SR-717. SR-301 shows higher potency than SR-717 by THP1-based ISRE reporter assay (EC50 = 0.6 vs. 2.1 μMrespectively) and shows good antitumor efficacy when administered orally in a murine B16.F10 melanoma tumor model in vivo (15 mg/kg/day p.o.).
References
[1] Luke L. LAIRSON, et al. Agonists of stimulator of interferon genes sting. Patent, WO2019165032A1