ChemicalBook CAS DataBase List 2369769-29-7

2369769-29-7

Name	Imidazo[1,2-c]pyrimidine-2-carbonitrile, 8-[4-[(dimethylamino)methyl]-2-methylphenyl]-5-[[(5-fluoro-2,3-dihydro-4-benzofuranyl)methyl]amino]-
CAS	2369769-29-7
Molecular Formula	C26H25FN6O
Molecular Weight	456.51
MOL File	2369769-29-7.mol

Chemical Properties

density	1.31±0.1 g/cm3(Predicted)
form	Solid
pka	8.73±0.28(Predicted)
color	White to off-white
InChIKey	FLCIOLFIDGTRCI-UHFFFAOYSA-N
SMILES	C1(NCC2=C3C(=CC=C2F)OCC3)=NC=C(C2=CC=C(CN(C)C)C=C2C)C2=NC(C#N)=CN12

Safety Data

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H302-H315-H319
Precautionary statements	P501-P270-P264-P280-P302+P352-P337+P313-P305+P351+P338-P362+P364-P332+P313-P301+P312+P330

Hazard Information

Spectrum Detail

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Animal Model:	KARPAS-422 DLBCL xenograft model^[1]
Dosage:	30, 100, 200 mg/kg
Administration:	Oral gavage (p.o.)
Result:	Had well tolerated at all dose levels assessed compared to tazemetostat at a clinically relevant dose.

Animal Model:	22Rv1 model
Dosage:	30 mg/kg
Administration:	Oral gavage (p.o.)
Result:	Made average tumor volume ± SEM, with n=8-10/group. Had a significant difference in ORIC-944 treatment group vs vehicle.

2369769-29-7

Chemical Properties

Safety Data

Hazard Information

Uses

in vivo

References

Spectrum Detail

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