Olaquindox is an antibiotic and a swine growth regulator.
1 In vivo, olaquindox (100 mg/kg) decreases
E. coli-induced diarrhea and the number of intraepithelial lymphocytes in the ileum and increases body weight in geld piglets. Olaquindox induces bleeding, intramuscular edema, vacuolar degeneration, and deformation of renal tubules in
C. carpio.
2 It decreases mean body weight and increases the number of dead fetuses in pregnant rats when administered at a dose of 110 mg/kg and increases the number of external deformities, including bent tail, craniorachischisis, exencephaly, and anophthalmia in rat pups born to exposed pregnant mothers.
3 Formulations containing olaquindox have been used as growth promoting agents in bovine livestock.
