2361418-52-0

PI3K/HDAC-IN-1 is a potent dual inhibitor of PI3K/HDAC, potently inhibits PI3Kδ and HDAC1 with IC50s of 8.1 nM and 1.4 nM, respectively[1]. PI3Kα|42 nM (IC50)|PI3Kβ|101 nM (IC50)|PI3Kγ|67 nM (IC50)|PI3Kδ|8.1 nM (IC50)|HDAC1|1.4 nM (IC50)|HDAC2|3.0 nM (IC50)|HDAC6|6.6 nM (IC50)|HDAC8|18 nM (IC50)

PI3K/HDAC-IN-1 is a potent dual inhibitor of PI3K/HDAC, potently inhibits PI3Kδ and HDAC1 with IC50s of 8.1 nM and 1.4 nM, respectively[1].

PI3Kα: 42 nM (IC₅₀); PI3Kβ: 101 nM (IC₅₀); PI3Kγ: 67 nM (IC₅₀); PI3Kδ: 8.1 nM (IC₅₀); HDAC1: 1.4 nM (IC₅₀); HDAC2: 3.0 nM (IC₅₀); HDAC6: 6.6 nM (IC₅₀); HDAC8: 18 nM (IC₅₀)

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[1]. Zhang K, et al. Design, Synthesis, and Biological Evaluation of 4-Methyl Quinazoline Derivatives as Anticancer Agents Simultaneously Targeting Phosphoinositide 3-Kinases and Histone Deacetylases. J Med Chem. 2019 May 29.