2358849-47-3

COX-1/2-IN-2 is a potent COX1/2 inhibitor. COX-1/2-IN-2 exhibits significant inhibitory effect against COX-1 and COX-2 inhibitor with IC50 values of 13.9?±?3.21?μM and 6.4±0.74?μM, respectively[1].

COX-1: 9.7±0.09 μM (IC₅₀); COX-2: 4.6±1.45 μM (IC₅₀)

[1] Malose J. Mphahlele, et al. Synthesis, in vitro and in silico enzyme (COX-1/2 & LOX-5), free radical scavenging and cytotoxicity profiling of the 2,4-dicarbo substituted quinazoline 3-oxides. Medicinal Chemistry Research?volume?31,?pages146–164 (2022)