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t-Boc-Aminooxy-PEG8-alcohol is an aqueous soluble reagent comprising a Boc-protected aminooxy group and an alcohol group. The protected aminooxy can be deprotected under mild acidic conditions and then can react with an aldehyde group to form a stable oxime linkage. The hydroxyl group enables further derivatization or replacement with other reactive functional groups.

t-Boc-Aminooxy-PEG8-alcohol is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

PEGs; Alkyl/ether

[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005