KuWal151 is a CLK1, CLK2 and CLK4 inhibitor with a high selectivity margin towards DYRK kinases. KuWal151 has potent antiproliferative activity in an array of cultured cancer cell lines[1].
References
[1] Walter A, et al. Molecular structures of cdc2-like kinases in complex with a new inhibitor chemotype. PLoS One. 2018 May 3;13(5):e0196761. DOI:10.1371/journal.pone.0196761
