23246-96-0

Colorless to yellowish crystalline solid. Starts turning brown at approximately 165℃; turns blackish- brown at 187℃.

ChEBI: A macrolide that is 13,19-didehydrosenecionan bearing two additional hydroxy substituents at positions 12 and 18 as well as two additional oxo groups at positions 11 and 16.

Colorless to off-white crystalline solid. Starts turning brown at approximately 329°F; is blackish-brown at melting point.

Exposure to light and air can cause gradual oxidation. Insoluble in water.

riddelline reacts readily with oxidizing agents (slowly with atmospheric oxygen). On contact with bases, hydrolysis will probably occur .

Flash point data for riddelline are not available; however, riddelline is probably combustible.

Riddelline is a natural alkaloid product used a laboratory chemical and reference standard.

Eyes: First check the victim for contact lenses and remove if present. Flush victim’s eyes with water or normal saline solution for 20?30 minutes while simulta- neously calling a hospital or poison control center. Do not put any ointments, oils, or medication in the victim’s eyes without specific instructions from a physician. Immediately transport the victim after flushing eyes to a hospital even if no symptoms (such as redness or irritation) develop. Skin: Immediately flood affected skin with water while removing and isolating all contaminated clothing. Gently wash all affected skin areas thoroughly with soap and water. If symptoms such as redness or irritation develop, immedi- ately call a physician and be prepared to transport the vic- tim to a hospital for treatment. Inhalation: Immediately leave the contaminated area; take deep breaths of fresh air. Immediately call a physician and be prepared to transport the victim to a hospital even if no symptoms (such as wheezing, coughing, shortness of breath, or burning in the mouth, throat, or chest) develop. Provide proper respiratory protection to rescuers entering an unknown atmosphere. Whenever possible, Self-Contained Breathing Apparatus (SCBA) should be used; if not available, use a level of pro- tection greater than or equal to that advised under Protective Clothing. Ingestion: If the victim is conscious and not convulsing, give one or two glasses of water to dilute the chemical and immediately call a hospital or poi- son control center. Generally, the induction of vomiting is not recommended outside of a physician’s care due to the risk of aspirating the chemical into the victim’s lungs. However, if the victim is conscious and not convulsing and if medical help is not readily available, consider the risk of inducing vomiting because of the high toxicity of the chem- ical ingested. Ipecac syrup or salt water may be used in such an emergency. Immediately transport the victim to a hospital. If the victim is convulsing or unconscious, do not give anything by mouth, ensure that the victim’s airway is open and lay the victim on his/her side with the head lower than the body. Do not induce vomiting. Immediately trans- port the victim to a hospital .

UN1544 Alkaloids, solid, n.o.s. or Alkaloid salts, solid, n.o.s. poisonous, Hazard Class: 6.1; Labels: 6.1-Poisonous materials, Technical Name Required.

Riddelline is sensitive to light, air, and heat, causing oxidation; reacts slowly with atmospheric oxygen. This chemical is probably combustible; dust mixed with air may be explosive. Incompatible with oxidizers (chlorates, nitrates, peroxides, permanganates, perchlorates, chlorine, bromine, fluorine, etc.); contact may cause fires or explosions. Keep away from alkaline materials, strong bases, strong acids, oxoacids, and epoxides. Contact with alkalis and bases may cause hydrolysis.

It is inappropriate and possi- bly dangerous to the environment to dispose of expired or waste product such as lab chemicals by flushing them down the toilet or discarding them to the trash. Larger quantities shall carefully take into consideration applicable EPA, and FDA regulations. If possible return the lab che- micals to the manufacturer for proper disposal being careful to properly label and securely package the material. Alternatively, the waste lab chemicals shall be labeled, securely packaged and transported by a state licensed medi- cal waste contractor to dispose by burial in a licensed haz- ardous or toxic waste landfill or incinerator.

Riddelliine-containing plants are not used for food in the United States, and riddelliine and riddelliine N-oxide have no known commercial uses. However, the riddelliine-containing plant Senecio longilobus has been used in medicinal herb preparations in the United States, and S. jacobaea and S. vulgaris, both of which have been shown to contain riddelliine, are used in medicinal preparations in other parts of the world (Mattocks 1986).

Riddelliine is reasonably anticipated to be a human carcinogen based on sufficient evidence of carcinogenicity from studies in experimental animals and supporting data from studies on mechanisms of carcinogenesis.