2302772-05-8

Top1 inhibitor 1 (compound 28) is a potent human topoisomerase I (Top1) inhibitor with an IC50 value of 29 nM[1].

Camptothecins

[1] Kundu B, et al. Discovery and Mechanistic Study of Tailor-Made Quinoline Derivatives as Topoisomerase 1 Poison with Potent Anticancer Activity. J Med Chem. 2019 Apr 11; 62(7):3428-3446. DOI:10.1021/acs.jmedchem.8b01938