The general procedure for the synthesis of 1-(2,5-dimethyl-4-oxazolyl)vinyl ketone, using the compound (CAS: 940879-48-1) as starting material, was as follows: first, 1-(2,5-dimethyloxazol-4-yl)ethanol (1.2 g, 8.50 mmol) was mixed with MnO2 (3.70 g, 42.5 mmol) in chloroform (85 mL). Subsequently, the reaction mixture was heated and stirred at 75 °C for 12 hours. Upon completion of the reaction, it was filtered through a diatomaceous earth pad to remove solid impurities. The filtrate was concentrated under reduced pressure to afford 1-(2,5-dimethyloxazol-4-yl)ethanone (750 mg, 5.39 mmol, 63.4% yield), the product was a light yellow oil, which solidified to a solid on standing. The NMR hydrogen spectrum (500 MHz, CDCl3) data of the product were as follows: δ 2.59 (s, 3H), 2.52 (s, 3H), 2.46 (s, 3H).
