22977-65-7

4-Palmitamido-2,2,6,6-tetramethylpiperidine-1-oxyl is an aliphatic derivative of TEMPO (T017850), a stable radical prepared through the oxidation of 2,2,6,6-tetramethylpiperidine.

This amphiphilic compound binds strongly to membranes by virture of its long hydrocarbon chain, but the polarity of the amide linkage is expected to localize the nitroxide function in the aqueous phase adjacent to the membrane surface. The location of the nitroxide function allows one to investigate electrostatic potentials and lipid-protein interactions at the membrane surface.