2284460-01-9

Name	1-Naphthaleneacetamide, N-[6-[3-(hydroxyamino)-3-oxo-1-propen-1-yl]-3-pyridinyl]-
CAS	2284460-01-9
Molecular Formula	C20H17N3O3
Molecular Weight	347.37
MOL File	2284460-01-9.mol

Synonyms

MC2590 1-Naphthaleneacetamide, N-[6-[3-(hydroxyamino)-3-oxo-1-propen-1-yl]-3-pyridinyl]-

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Chemical Properties

density	1.362±0.06 g/cm3(Predicted)
pka	8.63±0.23(Predicted)

Hazard Information

Uses

MC2590 is a potent pyridine-containing histone deacetylase (HDAC) inhibitor. MC2590 is a inhibitor of HDAC1-3, -6, -8, and -10 (class I/IIb-selective inhibitor) with IC50s of 0.015 μM-0.156 μM. MC2590 also inhibits HDAC isoforms HDAC4, HDAC5, HDAC7, HDAC9, HDAC11 with IC50s of 1.35 μM-3.98 μM. MC2625 induces G2/M cell cycle arrest and modulates pro- and anti-apoptotic microRNAs towards apoptosis induction[1].

IC 50

HDAC1: 0.098 μM (IC₅₀); HDAC2: 0.156 μM (IC₅₀); HDAC3: 0.039 μM (IC₅₀); HDAC6: 0.015 μM (IC₅₀); HDAC8: 0.047 μM (IC₅₀); HDAC10: 0.071 μM (IC₅₀); HDAC4: 2.73 μM (IC₅₀); HDAC5: 1.35 μM (IC₅₀); HDAC7: 2.06 μM (IC₅₀); HDAC9: 2.79 μM (IC₅₀); HDAC11: 3.98 μM (IC₅₀)

References

[1] Elisabetta Di Bello, et al. Novel pyridine-containing histone deacetylase inhibitors strongly arrest proliferation, induce apoptosis and modulate miRNAs in cancer cells. Eur J Med Chem. 2022 Dec 15;247:115022. DOI:10.1016/j.ejmech.2022.115022