2278278-04-7

FLT3/ITD-IN-4 (Compound 16) is a selective FMS-like tyrosine kinase 3 internal tandem duplications (FLT3-ITD) inhibitor with an IC50 of 2.3 nM. FLT3/ITD-IN-4 can be used for acute myeloid leukemia research[1].

FLT3-ITD: 2.3 nM (IC₅₀); FLT3 D835Y: 4.84 nM (IC₅₀); RET: 277 nM (EC₅₀); FLT3: 443 nM (EC₅₀); ZAK/MLTK: 1069 nM (EC₅₀); CDK16/Cyclin Y: 1768 nM (EC₅₀); DDR2: 2494 nM (EC₅₀); EPHA7: 3255 nM (EC₅₀); NTRK1: 3857 nM (EC₅₀); MAP4K4: 5737 nM (EC₅₀)

[1] Sellmer A, et al. A series of novel aryl-methanone derivatives as inhibitors of FMS-like tyrosine kinase 3 (FLT3) in FLT3-ITD-positive acute myeloid leukemia. Eur J Med Chem. 2020 May 1;193:112232. DOI:10.1016/j.ejmech.2020.112232