227002-04-2

L-764406 is a partial agonist of human peroxisome proliferator-activated receptor gamma.

L-764406 is a non-thiazolidinedione (TZD)-type PPARg nuclear receptor ligand with high affinity. L-764406 has significant binding ability to PPARg (IC50=70 nM). L-764406 exhibited partial agonist activity and induced expression of the adipocyte-specific gene aP2 in chimeric receptors expressing the PPARg LBD and the corresponding reporter gene, as well as in 3T3-L1 cells. In contrast, L-764406 showed no activity in cells transfected with chimeric receptors containing PPARa or PPARd LBDs[1].

[1] L-764406 Is a Partial Agonist of Human Peroxisome Proliferator-activated Receptor g