2254609-23-7

SJFδ is a 10-atom linker PROTAC based on von Hippel-Lindau ligand. SJFδ degrades p38δ with a DC50 of 46.17?nM, but does not degrade p38α, p38β, or p38γ[1].

p38α: 46.17 nM (DC₅₀); VHL

Store at -20°C

[1] Smith BE, et al. Differential PROTAC substrate specificity dictated by orientation of recruited E3 ligase. Nat Commun. 2019 Jan 10;10(1):131. DOI:10.1038/s41467-018-08027-7