General procedure for the synthesis of (5-bromopyrimidin-2-yl)methanol from the compound (CAS:1025351-12-5): (Step 4) Methyl (5-bromopyrimidin-2-yl)benzoate (7.30 g, 25.0 mmol) was dissolved in methanol (15 ml), to which a 1N sodium methanol/methanol solution (50.0 ml, 0.500 mmol) was added. The resulting mixture was stirred at room temperature until the deprotection reaction was complete. After completion of the reaction, the solvent was removed by distillation. The obtained residue was purified by silica gel column chromatography (eluent ratio: dichloromethane:methanol = 30:1 to 15:1) to afford the title compound (5-bromopyrimidin-2-yl)methanol (3.58 g, 76% yield). The product was characterized by 1H NMR (CDCl3, 400 MHz): δ 8.80 (s, 2H), 4.82 (d, J=4.0 Hz, 2H), 3.39 (s, 1H).
