2243136-03-8

JAK3/BTK-IN-6 (compound 14h) is a potent BTK and JAK3 dual inhibitor, with IC50 values of 0.6 and 0.4 nM, respectively. JAK3/BTK-IN-6 shows good metabolic stability in human liver microsome. JAK3/BTK-IN-6 can be used for hematological and immune diseases research[1].

JAK3: 0.4 nM (IC₅₀); JAK2: 657.9 nM (IC₅₀); JAK1: >1000 nM (IC₅₀); Tyk2: >1000 nM (IC₅₀)

[1] Ren J, et al. Design and synthesis of boron-containing diphenylpyrimidines as potent BTK and JAK3 dual inhibitors. Bioorg Med Chem. 2020 Jan 15;28(2):115236. DOI:10.1016/j.bmc.2019.115236