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CFTR corrector 6 is a potent potentiator of Cystic Fibrosis Transmembrane conductance Regulator (CFTR). CFTR corrector 6 has the potential for cystic fibrosis (CF) and other CFTR associated disorders research[1]. CFTR corrector 6 (Example 27) has EC50s of 1.25 nM and 1.27 nM for primary cystic fibrosis human bronchial epithelial (CF hBE) cells and fischer rat thyroid (FRT) cell lines[1].

[1]. Joseph Walter Strohbach, et al. Pyrrolopyrimidines as cftr potentiators. WO2018094137A1