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ABBV-3221, also known as GLPG-3221, is a Potent Corrector of CFTR for the Treatment of Cystic Fibrosis.

GLPG-3221 is a potent, orally active corrector of CFTR (cystic fibrosis transmembrane conductance regulator), with an EC50 of 105 nM. GLPG-3221 can be uesd for the treatment of cystic fibrosis[1].

[1] Scanio MJC, et al.Discovery?of?ABBV/GLPG-3221, a?Potent?Corrector?of?CFTR?for the Treatment of Cystic Fibrosis.ACS Med Chem Lett.?2019 Oct 31;10(11):1543-1548. DOI:10.1021/acsmedchemlett.9b00377