2204280-42-0

Name	MY33-3 (hydrochloride)
CAS	2204280-42-0
Molecular Formula	C16H14ClF6NS2
Molecular Weight	433.86
MOL File	2204280-42-0.mol

Synonyms

MY33-3 (hydrochloride) Benzenemethanamine, 4-[(trifluoromethyl)thio]-N-[[4-[(trifluoromethyl)thio]phenyl]methyl]-, hydrochloride (1:1)

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Chemical Properties

form	Solid
color	White to light yellow

Hazard Information

Uses

MY33-3 hydrochloride is a potent and selective inhibitor of receptor protein tyrosine phosphatase (RPTP)β/ζ, with an IC50 of ~0.1 μM. MY33-3 hydrochloride also inhibits PTP-1B (IC50 ~0.7 μM). MY33-3 hydrochloride can reduce ethanol consumption and alleviate Sevoflurane-induced neuroinflammation and cognitive dysfunction[1][2][3].

in vivo

MY33-3 hydrochloride (60 mg/kg; p.o. on days 3 and 4) reduces ethanol consumption when comparing day 2 with day 3. MY33-3 hydrochloride reduces preference for the ethanol solution on day 3^[1].
MY33-3 hydrochloride (i.p.) reverses the Sevoflurane-induced decrease in the discrimination index and impaired motor learning ability^[3].

References

[1] Fernández-Calle R, et, al. Pharmacological inhibition of Receptor Protein Tyrosine Phosphatase β/ζ (PTPRZ1) modulates behavioral responses to ethanol. Neuropharmacology. 2018 Jul 15;137:86-95. DOI:10.1016/j.neuropharm.2018.04.027
[2] Fernández-Calle R, et, al. Role of RPTPβ/ζ in neuroinflammation and microglia-neuron communication. Sci Rep. 2020 Nov 20;10(1):20259. DOI:10.1038/s41598-020-76415-5
[3] Mao S, et, al. Pleiotrophin Potentiates Sevoflurane Anesthesia-induced Learning Deficits in Mice. J Mol Neurosci. 2022 Jan;72(1):48-55. DOI:10.1007/s12031-021-01885-9

Supplier

Jinan Jiuli Biotechnology Co. , Ltd.

Telephone 15865264761

Websitehttps://www.chemicalbook.com/ShowSupplierProductsList89365/0.htm

TargetMol Chemicals Inc.

Telephone 4008200310

Websitehttps://www.targetmol.cn/

Shanghai Tachizaki Biomedical Research Center

Telephone 18014399201

Websitehttp://www.chemlab-tachizaki.com/

Nantong QuanYi Biotechnology Co., Ltd

Telephone0513-66337626 18051384581

Websitehttps://www.chemhifuture.com/

Shanghai Yifei Biotechnology Co. , Ltd.

Telephone021-65675885 18964387627

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Nantong HI-FUTURE Biology Co., Ltd.

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Websitehttps://www.chemhifuture.com/

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