2170766-56-8

Estrogen receptor modulator 8 (compound 4) is an orally active inhibitor of Estrogen Receptor/ERR α (IC50=0.437 nM, MCF-7 cells). Estrogen receptor modulator 8 inhibits MCF-7 cells proliferation with an IC50 value of 0.1 nM[1].

[1] Guan D, et al. Preparation of 3-[4-(tetrahydro-1H-pyrrolo[3,4-b]indol-1-yl)phenyl]acrylic acid compound useful as estrogen receptor down-regulator (SERD). World Intellectual Property Organization, WO2018001232 A1. 2018-01-04.