214558-72-2

YM-58790 (3 mg/kg, i.v.) has no effect on oxotremorine-induced tremor in mice^[1].
YM-58790 (6.0 mg/kg; i.v.) shows poor M1 and M2 antagonism effect in vivo on McN-A343-induced pressor in pithed rats, but displays potent efficacy on M3 antagonism with an ED₃₀ value of 0.36 mg/kg (i.v.) and an ID₅₀ value of 2.4 mg/kg (i.v.)^[1].
YM-58790 exhibits potent inhibitory activity on bladder pressuer in reflexly-evoked rhythmic contraction, similar to Oxybutynin.html" class="link-product" target="_blank">Oxybutynin (HY-B0267), and has about ten times less inhibitory effect on oxotremorine-induced salivary secretion than oxybutynin in rats^[1].