Description
A wide variety of species contain this quaternary alkaloid which is widespread
among the families, Aquilegia, Magnolia and Michelia. It has been isolated and
characterized as the iodide, m.p. 248-9°C (dec.); [0:11>5 + 200.1° (MeOH). The
optically inactive base also yields an iodide which crystallizes with 1.5 H20,
m.p. 243°C (dec.).
Uses
Magnoflorine-d3 is the labelled analogue of Magnoflorine, an isoquinoline alkaloid from the Coptis japonica and it enhances the myoblast differentiation through activation of the p38 MAP kinase and Akt pathway.
References
Nakano., Chem. Pharm. Bull. (Tokyo), 2, 329 (1954)
Tomita, Kikkawa.,J. Pharm. Soc., Japan, 77, 195 (1957)
Gopinath et aI., J. Sci. Ind. Res., 18B, 444 (1959)
Ishii, Harada.,J. Pharm. Soc., Japan, 81,238 (1961)
Yang, Lu, Hsiao., ibid, 82,794,816 (1962)
Yang, Lu, Hsiao., ibid, 83,216 (1963)
