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DBCO-NHCO-PEG4-NHS ester is a PEG linker containing NHS ester that is able to react specifically and efficiently with primary amines such as the side chain of lysine residues or aminosilane-coated surfaces at neutral or slightly basic condition to form a covalent bond. The hydrophilic PEG spacer arm improves water solubility and can also provide a long and flexible connection that minimizes steric hindrance during ligation. DBCO is commonly used for copper-free Click Chemistry reactions.

DBCO-NHCO-PEG4-NHS ester is a PROTAC linker, belonging to the PEG class and the Alkyl/ether class. It can be used to synthesize a series of PROTAC molecules. Also it is a cleavable ADC linker for the synthesis of antibody drug conjugates (ADCs).

Cleavable

PEGs

Alkyl/ether