2079892-79-6

Name	RORγt inhibitor 1
CAS	2079892-79-6
Molecular Formula	C26H33N7O2
MDL Number	MFCD34469367
Molecular Weight	475.59
MOL File	2079892-79-6.mol

Synonyms

RORγt inhibitor 1 RORγt Inverse agonist 8 (S)-N-(8-((4-(cyclopentanecarbonyl)-3-methylpiperazin-1-yl)methyl)-7-methylimidazo[1,2-a]pyridin-6-yl)-2-methylpyrimidine-5-carboxamide

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Chemical Properties

density	1.35±0.1 g/cm3(Predicted)
pka	10.15±0.46(Predicted)

Hazard Information

Description

GKN92796, also known as RORγt inhibitor 1, is a RORγt inhibitor. This product has no formal name at the moment.

Uses

RORγt Inverse agonist 8 is a potent, selective, orally bioavailable RORγt inverse agonist, with an IC50 of 19 nM for human RORγt-LBD[1].

in vivo

RORγt Inverse agonist 8 (15 mg/kg, 45 mg/kg ; i.g.; twice daily; for 7 days) ameliorates antigen-induced arthritis (AiA) responses in Lewis rats^[1].

Animal Model:	Female Lewis rats (190–220 g)^[1]
Dosage:	15 mg/kg, 45 mg/kg
Administration:	Oral gavage; twice daily; for 7 days
Result:	Ameliorates antigen-induced arthritis (AiA) responses in Lewis rats.

References

[1] Guendisch U, et al. Pharmacological inhibition of RORγt suppresses the Th17 pathway and alleviates arthritis in vivo. PLoS One. 2017 Nov 20;12(11):e0188391. DOI:10.1371/journal.pone.0188391

Supplier

Labnetwork lnc.

Telephone+86-27-50766799 +8618062016861

Websitewww.labnetwork.com

Beijing Jin Ming Biotechnology Co., Ltd.

Telephone010-60605840 15801484223;

Websitehttp://www.jm-bio.com/

TargetMol Chemicals Inc.

Telephone 15002134094

Websitehttps://www.targetmol.cn/

Biosynth Biological Technology (Suzhou) Co Ltd

Telephone 51288865780

Websitehttp://www.biosynth.com

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