Chemical Properties
Colorless to yellow liquid or low melting solid,
Uses
Chlorotriisopropoxytitanium(IV) solution may be used as a precursor for the synthesis of ultralow density ceramic materials. The product may be used to mediate a reductive amination reaction of 5α-cholestane-3,7-dione to yield aryl aminocholestanes.
Synthesis Reference(s)
1. Reetz, M. T.; Westermann, J.; Steinbach, R.; Wenderoth, B.; Peter, R.; Ostarek, R.; Maus, S. CB 1985, 118, 1421.
reaction suitability
core: titanium
reagent type: catalyst
Synthesis
Chlorotitanium triisopropoxide can be easily made from a 3:1 mixture of Titanium Tetraisopropoxide and Titanium(IV) Chloride,1 which can be distilled to give the pure reagent or used in situ.
Purification Methods
When distilled under vacuum, the distillate sets slowly to a solid on standing. Stock reagents are made by dissolving the warm liquid in pentane, toluene, Et2O, THF, CH2Cl2,, and can be stored in a pure state or in solution under dry N2 for several months. The reagent is hygroscopic and is hydrolysed by H2O. [Reetz et al. Chem Ber 118 1421 1985.]
Precautions
Chlorotitanium triisopropoxide is corrosive; moisture sensitive; flammable liquid; can be stored under nitrogen, in pure form or in solution, for months.
