2070015-26-6

SRT3025 Hydrochloride is a SIRT1 activator which in turn inhibits RANKL-induced osteoclastogenesis in bone marrow-derived macrophages. Decreases osteoclast-mediated bone resporption.

SRT3025 is an orally active sirtuin 1 activator (Sirt1 EC1.5 ≤1 μMEmax ≥150% and <300%) th at reduces cellular acetylation of Sirt1 substrates FoxO1 (induced by RANKL ) and histone 3 (1-10 μM; murine bone marrow macrophages) and exhibits in vivo efficacy in a murine atherosclerosis model (3.18 g/kg high-cholesterol diet; mice) and ovariectomy-induced bone loss in female mice (50 & 100 mg/kg via daily p.o.).

SIRT1: 1 μM (EC1.5)

Store at -20°C