Uses
FPT, a 2-Aminotetralin, is an efficacious partial agonist at 5-HT1AR, a full agonist at 5-HT1BR and 5-HT1DR with EC50s of 39.3 nM, 1.2 nM, 0.5 nM, respectively. FPT is a weak agonist at 5-HT7R. FPT shows in vivo efficacy as an antiepileptic in Fmr1 knockout mice and has anxiolytic-like and prosocial effects in Fmr1 knockout mice and other mouse models[1].
IC 50
5-HT1A Receptor: 39.3 nM (IC50); 5-HT1B Receptor: 1.2 nM (IC50); 5-HT1D Receptor: 0.5 nM (IC50); 5-HT1A Receptor: 4.3 nM (Ki); 5-HT1B Receptor: 2.3 nM (Ki); 5-HT1D Receptor: 1.2 nM (Ki); 5-HT1F Receptor: >10,000 nM (Ki); 5-HT7 Receptor
