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CAS DataBase List
2043670-02-4
2043670-02-4
Name
COX-2-IN-47
CAS
2043670-02-4
Molecular Formula
C18H18N2O4
Molecular Weight
326.35
MOL File
2043670-02-4.mol
Synonyms
COX-2-IN-47
Acetic acid, 2-[4-[4,5-dihydro-5-(4-methoxyphenyl)-1H-pyrazol-3-yl]phenoxy]-
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Chemical Properties
Boiling point
530.340±60.00 °C(Press: 760.00 Torr)(predicted)
density
1.290±0.14 g/cm3(Temp: 25 °C; Press: 760 Torr)(predicted)
pka
2.834±0.10(predicted)
Hazard Information
Uses
COX-2-IN-47 (compound 6c ) is a selective COX-2 inhibitor with IC50 value of 0.03 μM. COX-2-IN-47 has antiedema activity[1].
IC 50
COX-2: 0.03 μM (IC
50
)
References
[1] Elgohary MK, et al. Novel anti-inflammatory agents featuring phenoxy acetic acid moiety as a pharmacophore for selective COX-2 inhibitors: Synthesis, biological evaluation, histopathological examination and molecular modeling investigation. Bioorg Chem. 2024 Nov;152:107727. DOI:
10.1016/j.bioorg.2024.107727
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TargetMol Chemicals Inc.
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15002134094
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https://www.targetmol.cn/
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