201939-40-4

Name	PTAC oxalate
CAS	201939-40-4
Molecular Formula	C14H21N3O4S2
MDL Number	MFCD22683846
Molecular Weight	359.46
MOL File	201939-40-4.mol

Synonyms

PTAC oxalate (1R,5R,6R)-6-[4-(Propylthio)-1,2,5-thiadiazol-3-yl]-1-azabicyclo[3.2.1]octane oxalate

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Chemical Properties

storage temp.	Desiccate at RT
solubility	Soluble to 100 mM in water and to 100 mM in DMSO
form	Powder

Hazard Information

Uses

PTAC Oxalate is a muscarinic receptor ligand. Shows partial agonist activity at the M2 and M4 receptors, with minor antagonistic activity at m1, m3, m5 receptors. Inhibits firing rate of dopaminergic cells. Neuroprotective product.

in vivo

PTAC oxalate (0.01, 0.05 mg/kg; IP) alleviates the mechanical allodynia in 0.05 mg/kg. PTAC oxalate decreases the immobility time of mice from both the sham and nerve injury groups at the dose of 0.05 mg/kg, but not at the dose of 0.01 mg/kg^[2].

Animal Model:	Mouse model of neuropathic pain^[2]
Dosage:	0.01, 0.05 mg/kg
Administration:	IP
Result:	The mechanical allodynia was alleviated with 0.05 mg/kg. At 0.05 mg/kg increased the paw withdrawal thresholds (PWTs) of the nerve-injury groups injected at day 4 after nerve injury. At 0.01 mg/kg had no effect on the PWTs in the sham and nerve-injury groups injected at day 14 after nerve injury.

IC 50

mAChR1: 0.6 nM (Ki); mAChR2: 2.8 nM (Ki); mAChR3: 0.2 nM (Ki); mAChR4: 0.2 nM (Ki); mAChR5: 0.8 nM (Ki)

Supplier

Energy Chemical

Telephone400-0056266

Websitehttp://www.energy-chemical.com

MedBioPharmaceutical Technology Inc

Telephone021-69568360 18916172912

Websitehttp://www.med-bio.cn/

Kaifeng Mingren Pharmaceutical Co.,LTD

Telephone0371-65741762

Websitehttps://www.kfmryy.com/

TargetMol Chemicals Inc.

Telephone4008200310 15002144251

Websitehttps://www.targetmol.cn/

Nantong QuanYi Biotechnology Co., Ltd

Telephone0513-66337626 18051384581

Websitehttps://www.chemhifuture.com/

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