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Acetyl hexapeptide-49 (example 13) is a bioactive peptide with anti-allergen effect and has been reported used as a cosmetic ingredient. Acetyl hexapeptide-49 can alleviate stimulation of mammalian skin cells and protect cell vitality[1][2].

[1] Resende DISP, et al.F. Usage of Synthetic Peptides in Cosmetics for Sensitive Skin. Pharmaceuticals (Basel). 2021;14(8):702.
[2] Synergistic compositions comprising acetyl hexapeptides and methods for mitigating skin irritation and enhancing skin barrier function. United States, US20160206543 A1. 2016-07-21.