193359-26-1

Co 101244 is a highly selective N-methyl-D-aspartate NR2B subtype antagonist.

Novel, potent and selective antagonist of NR2B-containing NMDA receptors (IC 50 values are 0.043, > 100 and > 100 μ M for NR1A/2B, NR1A/2A and NR1A/2C subunit combinations respectively). Displays neuroprotective effects in vivo and in vitro .