ChemicalBook CAS DataBase List 1912399-75-7

1912399-75-7

Name	BT11
CAS	1912399-75-7
Molecular Formula	C30H24N8O2
Molecular Weight	528.56
MOL File	1912399-75-7.mol

Chemical Properties

Boiling point	923.4±75.0 °C(Predicted)
density	1.424±0.06 g/cm3(Predicted)
solubility	DMSO: Soluble: =10 mg/ml
form	Solid
pka	10.24±0.10(Predicted)

Hazard Information

Uses

BT-11 is an orally available LANCL2 binding compound for treating inflammatory bowel disease.

Biological Activity

BT11 is an orally active compound that binds to lanthionine synthetase C-like 2 (LANCL2) with a Kd value of 7.7 μM and can be used for the treatment of inflammatory bowel disease.

in vivo

Oral administration of 8 mg/kg/day BT-11 to mice attenuates colitis. In the drug safety testing experiment in rats, oral high concentrations of BT-11 have good safety (detection concentration up to 1000 mg/kg/day).

target

References

[1] Carbo A, et al. An N,N-Bis(benzimidazolylpicolinoyl)piperazine (BT-11): A Novel Lanthionine Synthetase C-Like 2-Based Therapeutic for Inflammatory Bowel Disease. J Med Chem. 2016 Nov 23;59(22):10113-10126. DOI:10.1021/acs.jmedchem.6b00412
[2] Bissel P, et al. Exploratory Studies With BT-11: A Proposed Orally Active Therapeutic for Crohn's Disease. Int J Toxicol. 2016 Sep;35(5):521-9. DOI:10.1177/1091581816646356

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Target	Value
LANCL2 ()