ChemicalBook CAS DataBase List 191217-81-9

191217-81-9

Name	Pramipexole
CAS	191217-81-9
EINECS(EC#)	1806241-263-5
Molecular Formula	C10H21Cl2N3OS
MDL Number	MFCD00876894
Molecular Weight	302.26
MOL File	191217-81-9.mol

Synonyms

Mirapex Pra-API Pramipexole Unii-3D867np06j PPX dihydrochloride Pramipexole HCl hydrate Mirapex,Sifrol,Mirapexin Pramipexole 2HCl Hydrate PraMipexole dihydrochloride Monohy PraMipexole dihydrochloride hydrate Pramipexole (hydrochloride hydrate) Pramipexole Dihydrochloride Monohyd Pramipexole dihydrochloride 1-hydrate Pramipexole for system suitability CRS PraMipexole dihydrochloride Monohyrate Pramipexole dihydrochloride monohydrate PramipexoleDihydrochlorideMonohydrate&gt Pramipexole dihydrochloride monohydrate CRS 99.9%, Pramipexole Dihydrochloride Monohydrate? Pramipexole Dihydrochloride Monohydrate (200 mg) Pramipexole hydrochloride（Dihydrochloride monohydrate） Pramipexole Dihydrochloride Monohydrate DISCONTINUED, offer P700755 or P700750 (6S)-N'-Propyl-4,5,6,7-tetrahydro-1,3-benzothiazole-2,6-diamine hydrate dihydrochloride (S)-2-Amino-4,5,6,7-tetrahydro-6-(propylamino)benzothiazole dihydrochloride monohydrate (S)-2-Amino-6-(propylamino)-4,5,6,7-tetrahydrobenzothiazol2HClH2Otetrahydrobenzothiazol 2,6-BenzothiazolediaMine,4,5,6,7-tetrahydro-N6-propyl-,hydrochloride,hydrate(1:2:1),(6S)- (6S)- 4,5,6,7-tetrahydro-N6-propyl-2,6-benzothiazolediamine,hydrochloride,hydrate (1:2:1) (6S)-6-N-propyl-4,5,6,7-tetrahydro-1,3-benzothiazole -2,6-diamine hydrate dihydrochloride 2,6-Benzothiazolediamine, 4,5,6,7-tetrahydro-N6-propyl-, dihydrochloride, monohydrate, (6S)-

Chemical Properties

Appearance	White or almost white, crystalline powder.
Melting point	290 °C(dec.)
storage temp.	2-8°C
solubility	Freely soluble in water, soluble in methanol, sparingly soluble or slightly soluble in ethanol (96 per cent), practically insoluble in methylene chloride.
form	neat
color	White to Almost white
Merck	14,7705
BCS Class	1
InChI	InChI=1/C10H17N3S.ClH.H2O/c1-2-5-12-7-3-4-8-9(6-7)14-10(11)13-8;;/h7,12H,2-6H2,1H3,(H2,11,13);1H;1H2/t7-;;/s3
InChIKey	ZTZQAWQFTIVKMU-DCFBZVEJNA-N
SMILES	NC1SC2C[C@@H](NCCC)CCC=2N=1.Cl.O \|&1:5,r\|

Safety Data

WGK Germany	3
RTECS	DL3375000
HS Code	2934200000

Hazard Information

Chemical Properties

White or almost white, crystalline powder.

Uses

Antidepressant; antiparkinsonian; antischizophrenic; dopamine agonist.

Definition

ChEBI: A hydrate that is the monohydrate of the dihydrochloride salt of pramiprexole.

Brand name

Mirapex (Boehringer Ingelheim).

Description

Pramipexole dihydrochloride monohydrate is an activator of D2DR, D3DR and D4DR. Pramipexole has been found to have neuroprotective effects independent of its dopamine receptor agonism. It reduces mitochondrial reactive oxygen species (ROS) production and inhibits the activation of apoptotic pathways.

General Description

Pramipexole Dihydrochloride is a non-ergot dopamine agonist widely used for the treatment of early and advanced Parkinson′s disease (PD). It is also used to treat restless legs syndrome.
Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.

Clinical Use

Parkinson’s disease

Symptomatic treatment of restless legs

Side effects

Dizziness, lightheadedness, or fainting, especially when standing up suddenly from a sitting/lying position.
drowsiness.
nausea.
seeing, hearing, or feeling things that are not there.
trouble sleeping.
twitching, twisting, or other unusual body movements.
unusual tiredness or weakness.

Drug interactions

Potentially hazardous interactions with other drugs
Avoid concomitant use with antipsychotics.

Metabolism

Pramipexole undergoes <10% metabolism to inactive metabolites.
More than 90% of a dose is excreted via renal tubular secretion unchanged into the urine.

Spectrum Detail

Supplier

Guangzhou Isun Pharmaceutical Co., Ltd

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Jinan Yuantai Pharmaceutical Co.,Ltd

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Guangzhou Dreampharm Biotechnology Co., Ltd.

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Shandong Mingfeng Pharmaceutical and Technology Co. Ltd

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Shanghai Boyle Chemical Co., Ltd.

Telephone

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J & K SCIENTIFIC LTD.

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Chembest Research Laboratories Limited

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TCI (Shanghai) Development Co., Ltd.

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JinYan Chemicals(ShangHai) Co.,Ltd.

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Jia Xing Isenchem Co.,Ltd

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Adamas Reagent, Ltd.

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China DongFan Chemical Co.,LTD

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Wuhan Sunrise Technology Development Co., Ltd.

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Sinopharm Chemical Reagent Co,Ltd.

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Dalian Meilun Biotech Co., Ltd.

Telephone0411-62910999 13889544652

Websitehttp://www.meilunbio.com/

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