190842-36-5

Name	2-[N-(4-Chlorophenyl)-N-MethylaMino]-4H-pyrido[3,2-e]-1,3-thiazin-4-one
CAS	190842-36-5
Molecular Formula	C14H10ClN3OS
MDL Number	MFCD07772337
Molecular Weight	303.767
MOL File	190842-36-5.mol

Synonyms

YM 928 2-[(4-Chlorophenyl)methylamino]-4H-pyrido[3,2-e]-1,3-thiazin-4-one 4H-Pyrido[3,2-e]-1,3-thiazin-4-one, 2-[(4-chlorophenyl)methylamino]- 2-[N-(4-Chlorophenyl)-N-MethylaMino]-4H-pyrido[3,2-e]-1,3-thiazin-4-one

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Chemical Properties

Boiling point	503.9±56.0 °C(Predicted)
density	1.42±0.1 g/cm3 (20 ºC 760 Torr)
pka	-1.75±0.20(Predicted)

Hazard Information

Uses

YM928 is an orally active and noncompetitive α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor antagonist. YM928 inhibits AMPA receptor-mediated toxicity in primary rat hippocampal cultures with an IC50 value of 2 μM. YM928 blocks AMPA-induced intracellular calcium influx with an IC50 value of 3 μM and antagonizes AMPA-induced inward currents with an IC50 value of 1 μM. YM928 is promising for research of neurological disorders[1].

References

[1] Ohno K, et al. Functional characterization of YM928, a novel moncompetitive alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor antagonist. J Pharmacol Exp Ther. 2003 Jul;306(1):66-72. DOI:10.1124/jpet.103.049973

Supplier

Tianjin Derchemist Science & Technology Co., Ltd.

Telephone22-58627059 13920586291

Websitehttp://www.derchemist.com

Shanghai T&W Pharmaceutical Co., Ltd.

Telephone+86 21 61551611

Websitehttp://www.trustwe.com

Amadis Chemical Company Limited

Telephone571-89925085

Websitehttp://www.amadischem.com

Jinan ponder chemical co. LTD

Telephone0531-0000

Websitehttps://www.chemicalbook.com/ShowSupplierProductsList546697/0_EN.htm

TargetMol Chemicals Inc.

Telephone 15002134094

Websitehttps://www.targetmol.cn/

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