189061-11-8

NGB 2904 Hydrochloride is a dopamine D3 receptor antagonist that inhibits cocaine’s rewarding effects and cocaine-induced reinstatement of drug seeking behavior in rats.

Inhibition of dopamine D3 receptor function by NGB 2904 increases spontaneous locomotor activity in rodents.''NGB 2904 is a potent and selective dopamine D3 receptor antagonist with a D3/D2 ratio of 800 for r at and high binding affinity (1.4 nM) at the hD3 receptor with 150-fold selectivity for primate D3 receptors over primate D2L receptors. It attenuates the rewarding effects of cocaine and methamphetamine.

D₃ Receptor: 1.4 (Ki)

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