Anti-aging agent 1 (compound 24) is a derivative of piperlongumine (HY-N2329) (PL). Anti-aging agent 1 exhibits a 50-fold enhancement in senolytic activity against senescent WI-38 fibroblasts compared to PL[1].
References
[1] Xuan Zhang, et al. Design and optimization of piperlongumine analogs as potent senolytics. Bioorg Med Chem Lett. 2023. DOI:10.1016/j.bmcl.2023.129593
